三氟甲烷磺酸三甲硅基甲酯[三甲基硅甲化试剂]

三氟甲烷磺酸三甲硅基甲酯[三甲基硅甲化试剂] - Names and Identifiers

Name	Trimethylsilylmethyltrifluoromethanesulfonate
Synonyms	TRIMETHYLSILYLMETHYL TRIFLATE trimethylsilylmethylatingreagent Trimethylsiylmethyltrifluoromethanesulfnate Trimethylsilylmethyltrifluoromethanesulfonate (TRIMETHYLSILYL)METHYL TRIFLUOROMETHANESULFONATE TriMethylsilyl trifluoroMethane sulfonic acid Methyl ester TRIFLUOROMETHANESULFONIC ACID (TRIMETHYLSILYL)METHYL ESTER (Trimethylsilyl)methyl Trifluoromethanesulfonate [Trimethylsilylmethylating Reagent]
CAS	64035-64-9
InChI	InChI=1/C5H11F3O3SSi/c1-13(2,3)4-11-12(9,10)5(6,7)8/h4H2,1-3H3

三氟甲烷磺酸三甲硅基甲酯[三甲基硅甲化试剂] - Physico-chemical Properties

Molecular Formula	C5H11F3O3SSi
Molar Mass	236.28
Density	1.182g/mLat 25°C(lit.)
Melting Point	<0°C
Boling Point	49-51°C9mm Hg(lit.)
Flash Point	119°F
Vapor Presure	2.1mmHg at 25°C
Appearance	clear liquid
Specific Gravity	1.182
Color	Colorless to Light yellow
BRN	2365813
Storage Condition	2-8°C
Sensitive	7: reacts slowly with moisture/water
Refractive Index	n20/D 1.376(lit.)
MDL	MFCD00009914

三氟甲烷磺酸三甲硅基甲酯[三甲基硅甲化试剂] - Risk and Safety

Hazard Symbols	C - Corrosive
Risk Codes	R10 - Flammable R34 - Causes burns
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S16 - Keep away from sources of ignition.
UN IDs	UN 2920 8/PG 2
WGK Germany	3
FLUKA BRAND F CODES	8-10-21
TSCA	No
HS Code	29319090
Hazard Class	3.2
Packing Group	III

三氟甲烷磺酸三甲硅基甲酯[三甲基硅甲化试剂] - Introduction

Trimethylsilylmethyltrifluoromethanesulfonate is an organic compound with the chemical formula (C3H9Si) (CF3SO3), often abbreviated as TMSOTf. The following is a description of its nature, use, preparation and safety information:

Nature:
TMSOTf is a colorless to slightly yellow liquid that is volatile at room temperature. It has high thermal and chemical stability and can be used under a wide range of reaction conditions. It is stable in air, but sensitive to water and moisture.

Use:
TMSOTf is widely used in organic synthesis. Its main uses include:
1. as a conversion reagent: TMSOTf can convert compounds such as alcohols, acids and amines into corresponding sulfonates, esters and amides.
2. As a catalyst: TMSOTf can be used as an acid catalyst in many chemical reactions, such as Marchin blocking reaction and disease acylation reaction.
3. As an activator: TMSOTf can activate halogenated hydrocarbons and boric acid esters and other substrates to promote their reactions with other compounds.

Preparation Method:
Generally, the method for preparing TMSOTf is to first synthesize sulfonyl fluoride (SO2F2), and then react with methyl trifluoromethane thiol (CF3SH) to obtain TMSOTf. The preparation process requires attention to the safety of operating conditions and the toxicity of gaseous sulfonyl fluoride.

Safety Information:
TMSOTf is a corrosive compound that requires the use of protective gloves, goggles, protective clothing, etc. It is irritating to the skin and eyes and may have adverse health effects when inhaled or ingested. Contact with water and moisture should be avoided during use. Storage should be sealed, in a well-ventilated place away from fire and sparks. When handling and disposing of waste, it should be handled in accordance with relevant regulations.

Last Update：2024-04-10 22:29:15